Journal of Veterinary Science and Animal Welfare

Many researchers have studied the oxytetracycline (OTC) pharmacokinetic profile following oral administration in multiple aquatic animal species including shrimp[1-5], sea turtles[6], and fish[7-11], However, Rigos & Smith[12], described the void of data in the literature showing a clinical effect of OTC in fish that could be directly predicted, correlated, or assessed from OTC concentrations in the blood. OTC is approved by the US Food and Drug Administration (FDA) as an oral antibacterial to treat many bacterial infections in terrestrial animals and humans. It is also approved under the trade name, Terramycin® 200 for Fish (Phibro Animal Health) to treat specific diseases in salmonids, catfish, and lobster[13] (Table 1).